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Literature summary for 4.6.1.16 extracted from

  • Popow, J.; Englert, M.; Weitzer, S.; Schleiffer, A.; Mierzwa, B.; Mechtler, K.; Trowitzsch, S.; Will, C.L.; Luehrmann, R.; Soell, D.; Martinez, J.
    HSPC117 is the essential subunit of a human tRNA splicing ligase complex (2011), Science, 331, 760-764.
    View publication on PubMed
Search for more literature for 4.6.1.16

Protein Variants

Protein Variants Comment Organism
C122A inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pretRNA Homo sapiens
-
 a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phospho-double stranded-RNA
-
 Homo sapiens ?
-
 ?
pretRNA
-
 Homo sapiens a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus
-
 ?

Synonyms

Synonyms Comment Organism
HSPC117 subunit Homo sapiens
tRNA splicing ligase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction epleting HSPC117 by RNA interference abolishes interstrand ligation and impaires processing of pre-tRNA transcripts into mature tRNA in cell extracts Homo sapiens