Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.14 extracted from

  • Morris, J.C.; Ping-Sheng, L.; Shen, T.Y.; Mensa-Wilmot, K.
    Glycan requirements of glycosylphosphatidylinositol phospholipase C from Trypanosoma brucei. Glucosaminylinositol derivatives inhibit phosphatidylinositol phospholipase C (1995), J. Biol. Chem., 270, 2517-2524.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation by aminoglycoside antibiotic geneticin (G418) Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
Glucosaminyl-alpha-1,6-2-deoxy-D-myo-inositol i.e. compound VP-615L, more effective than VP-606L Trypanosoma brucei
Glucosaminyl-alpha-1,6-D-myo-inositol i.e. compound VP-606L or 6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-D-myo-inositol Trypanosoma brucei
Glucosaminyl-alpha-1,6-D-myo-inositol 1,2-cyclic phosphate i.e. compound VP-601L, product inhibition Trypanosoma brucei
Glucosaminyl-alpha-1,6-D-myo-inositol 1-dodecylphosphonate i.e. compound VP-604L Trypanosoma brucei
Glucosaminyl-alpha-1,6-D-myo-inositol 1-hexylphosphonate i.e. compound VFT-2 Trypanosoma brucei
glucosaminyl-alpha-1,6-D-myo-inositol 1-phosphate i.e. compound VP-600L Trypanosoma brucei
Inositol 1-dodecylphosphonate i.e. compound VP-602L Trypanosoma brucei
Mannosyl-alpha-1,4-glucosaminyl-alpha-1,6-D-myo-inositol i.e. O-alpha-D-mannopyranosyl-1,4-O-2-amino-2-deoxy-alpha-D-glucopyranosyl-1,6-D-myo-inositol Trypanosoma brucei
additional information no inhibition by palmitate, myristate, phosphatidylethanolamine, inositol 1-phosphate, N-acetylglucosamine, ethanolamine, inositol, glucosamine, mannose, glucosaminyl-alpha-1,6-2-deoxy-D-myo-inositol 1-phosphate (i.e. VP-612L), glucosaminyl-alpha-1,6-2-deoxy-L-myo-inositol (i.e. VP-614L) Trypanosoma brucei
N-(N,N-Dimethylcarbamyl)-glucosaminyl-alpha-1,6-D-myo-inositol i.e. compound VC-109B, less effective than VP-606L Trypanosoma brucei
N-Acetylglucosaminyl-alpha-1,6-D-myo-inositol i.e. compound VC-105B, weak Trypanosoma brucei
phosphatidylcholine weak Trypanosoma brucei
phosphatidylglycerol
-
Trypanosoma brucei
phosphatidylinositol
-
Trypanosoma brucei
phosphatidylserine
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
protozoan parasite
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information glucosaminyl(alpha1-, 6)inositol is the crucial glycan moiety for substrate recognition Trypanosoma brucei ?
-
?
phosphatidylinositol very poor substrate Trypanosoma brucei inositol 1,2-cyclic phosphate + inositol phosphate
-
?
variant-surface-glycoprotein
-
Trypanosoma brucei 1,2-didecanoylglycerol + soluble variant-surface-glycoprotein i.e. 1,2-dimyristoylglycerol ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Trypanosoma brucei