Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.14 extracted from

  • Fouchier, F.; Baltz, T.; Rougon, G.
    Identification of glycosylphosphatidylinositol-specific phospholipases C in mouse brain membranes (1990), Biochem. J., 269, 321-327.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.14

Activating Compound

Activating Compound Comment Organism Structure
butanol activation, 2% v/v, acidic enzyme form, not neutral enzyme form Mus musculus
deoxycholate activation, 0.5-1 mg/ml, neutral enzyme form, not acidic enzyme form, inhibits above 1 mg/ml Mus musculus
additional information 2 enzyme forms differing in pH-optima and response to stimulation by butanol and deoxycholate Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cetrimide i.e. alkyltrimethylammonium bromide, 0.3 mg/ml, neutral enzyme form Mus musculus
deoxycholate neutral enzyme form, above 1 mg/ml, activation at 0.5-1 mg/ml Mus musculus
EGTA Ca2+ reverses, only acidic, not neutral enzyme form Mus musculus
additional information no inhibition by Mn2+ Mus musculus
Nonidet P-40 above 0.1% w/v, neutral enzyme form Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane neutral enzyme form Mus musculus
-
-
lysosome predominantly acidic enzyme form Mus musculus 5764
-
membrane
-
 Mus musculus 16020
-
additional information subcellular localization in mouse brain membranes Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
myelin neutral enzyme form Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
variant-surface-glycoprotein highly specific Mus musculus 1,2-didecanoylglycerol + soluble variant-surface-glycoprotein
-
 ?
variant-surface-glycoprotein isolated from Trypanosoma equiperdum BoTat-1 Mus musculus 1,2-didecanoylglycerol + soluble variant-surface-glycoprotein
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5 5 acidic enzyme form Mus musculus
6.5 7 neutral enzyme form Mus musculus