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Literature summary for 4.6.1.1 extracted from

  • Pinto, C.; Lushington, G.H.; Richter, M.; Gille, A.; Geduhn, J.; Koenig, B.; Mou, T.C.; Sprang, S.R.; Seifert, R.
    Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases (2011), Biochem. Pharmacol., 82, 358-370.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Inhibitors

Inhibitors Comment Organism Structure
2',3'-O-(N-anthraniloyl)-ADP
-
 Homo sapiens
2',3'-O-(N-anthraniloyl)-ATP
-
 Homo sapiens
2',3'-O-(N-anthraniloyl)-IMP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-ADP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-ATP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-CDP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-CTP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-GTP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-GTPgammaS potent inhibitor of isoform AC5 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-IDP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-IMP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-ITP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-ITPgammaS potent inhibitor of isoform AC5 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-UDP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-UTP
-
 Homo sapiens
2',3'-O-(N-methylanthraniloyl)-XTP
-
 Homo sapiens
2'-deoxy-3'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate
-
 Homo sapiens
2'-deoxy-3'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Homo sapiens
3'-deoxy-2'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate
-
 Homo sapiens
3'-deoxy-2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens
-
 3',5'-cyclic AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cyclic AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1 isoform Homo sapiens
AC2 isoform Homo sapiens
AC5 isoform Homo sapiens
adenylyl cyclase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000012
-
 2',3'-O-(N-methylanthraniloyl)-ITP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0000028
-
 2',3'-O-(N-methylanthraniloyl)-ITP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000014
-
 2',3'-O-(N-methylanthraniloyl)-ITP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000031
-
 2',3'-O-(N-methylanthraniloyl)-IDP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000032
-
 2',3'-O-(N-methylanthraniloyl)-ITPgammaS isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000032
-
 2',3'-O-(N-methylanthraniloyl)-UTP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000034
-
 2',3'-O-(N-methylanthraniloyl)-GTPgammaS isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000039
-
 2',3'-O-(N-methylanthraniloyl)-IDP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00004
-
 2',3'-O-(N-methylanthraniloyl)-ITPgammaS isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000046
-
 2',3'-O-(N-methylanthraniloyl)-UTP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000053
-
 2',3'-O-(N-methylanthraniloyl)-GTP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000063
-
 2',3'-O-(N-methylanthraniloyl)-GTPgammaS isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000065
-
 3'-deoxy-2'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.000086
-
 2',3'-O-(N-methylanthraniloyl)-IDP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00009
-
 2',3'-O-(N-methylanthraniloyl)-GTP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0001
-
 2',3'-O-(N-methylanthraniloyl)-ATP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00012
-
 2',3'-O-(N-methylanthraniloyl)-ITPgammaS isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00012
-
 2',3'-O-(N-anthraniloyl)-ATP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00013
-
 2',3'-O-(N-anthraniloyl)-ATP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00015
-
 2',3'-O-(N-methylanthraniloyl)-ATP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00015
-
 2',3'-O-(N-methylanthraniloyl)-CTP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00015
-
 2',3'-O-(N-methylanthraniloyl)-CTP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00027
-
 2'-deoxy-3'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00032
-
 2'-deoxy-3'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00033
-
 2',3'-O-(N-methylanthraniloyl)-ATP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00034
-
 2',3'-O-(N-methylanthraniloyl)-UDP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00036
-
 2'-deoxy-3'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00037
-
 2',3'-O-(N-methylanthraniloyl)-GTPgammaS isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00039
-
 2',3'-O-(N-methylanthraniloyl)-UDP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00041
-
 2'-deoxy-3'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00046
-
 2',3'-O-(N-methylanthraniloyl)-UTP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00047
-
 3'-deoxy-2'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00054
-
 3'-deoxy-2'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00058
-
 2',3'-O-(N-methylanthraniloyl)-CDP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00061
-
 2',3'-O-(N-methylanthraniloyl)-GTP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00064
-
 2',3'-O-(N-anthraniloyl)-ATP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00064
-
 2',3'-O-(N-anthraniloyl)-ADP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00069
-
 2',3'-O-(N-methylanthraniloyl)-CTP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00074
-
 2',3'-O-(N-methylanthraniloyl)-CDP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00079
-
 2',3'-O-(N-methylanthraniloyl)-ADP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.00086
-
 2',3'-O-(N-anthraniloyl)-ADP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0011
-
 2',3'-O-(N-methylanthraniloyl)-XTP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0013
-
 2',3'-O-(N-methylanthraniloyl)-ADP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0013
-
 2'-deoxy-3'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0013
-
 2',3'-O-(N-methylanthraniloyl)-XTP isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0018
-
 3'-deoxy-2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0018
-
 3'-deoxy-2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate isoform AC5, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0027
-
 2',3'-O-(N-methylanthraniloyl)-UDP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0029
-
 2',3'-O-(N-anthraniloyl)-ADP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0029
-
 2',3'-O-(N-methylanthraniloyl)-ADP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.003
-
 2',3'-O-(N-methylanthraniloyl)-XTP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0037
-
 2',3'-O-(N-methylanthraniloyl)-CDP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0043
-
 2',3'-O-(N-anthraniloyl)-IMP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0044
-
 2',3'-O-(N-methylanthraniloyl)-IMP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0048
-
 2'-deoxy-3'-O-[2-(methylamino)benzoyl]adenosine 5'-triphosphate isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0068
-
 2',3'-O-(N-methylanthraniloyl)-IMP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0074
-
 2',3'-O-(N-anthraniloyl)-IMP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0075
-
 2',3'-O-(N-anthraniloyl)-IMP isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0085
-
 2',3'-O-(N-methylanthraniloyl)-IMP isoform AC1, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens
0.0087
-
 3'-deoxy-2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate isoform AC2, in 75 mM Tris/HCl, pH 7.4, at 37°C Homo sapiens