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Literature summary for 4.6.1.1 extracted from

  • Erdorf, M.; Seifert, R.
    Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes (2011), Naunyn Schmiedebergs Arch. Pharmacol., 383, 357-372.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
epinephrine significantly activates cortical adenylyl cyclase Oryctolagus cuniculus
forskolin significantly activates cortical adenylyl cyclase Oryctolagus cuniculus
glucagon 0.04 mM glucagon significantly activates cortical and medulla adenylyl cyclase Oryctolagus cuniculus
isoproterenol significantly activates cortical adenylyl cyclase Oryctolagus cuniculus
additional information not activated by histamine and 5-HT Oryctolagus cuniculus
norepinephrine significantly activates cortical adenylyl cyclase Oryctolagus cuniculus
[8-arginine]vasopressin 0.01 mM [8-arginine]vasopressin significantly activates cortical and medulla adenylyl cyclase Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
2'(3')-O-(N-methylanthraniloyl)-ATP
-
 Oryctolagus cuniculus
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS
-
 Oryctolagus cuniculus
2'(3')-O-(N-methylanthraniloyl)-CTP
-
 Oryctolagus cuniculus
2'(3')-O-(N-methylanthraniloyl)-GTP
-
 Oryctolagus cuniculus
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS
-
 Oryctolagus cuniculus
2'(3')-O-(N-methylanthraniloyl)-ITP highest potency on both cortical and medullary adenylyl cyclase in presence of Mn2+ as well as in presence of Mg2+ Oryctolagus cuniculus
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS
-
 Oryctolagus cuniculus
2'(3')-O-(N-methylanthraniloyl)-UTP
-
 Oryctolagus cuniculus
Ca2+ cortical adenylyl cyclase AC5 is sensitive to inhibition by Ca2+ Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 ATP cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.027
-
 ATP medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.086
-
 ATP cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.13
-
 ATP medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Oryctolagus cuniculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+ is the physiological cation involved in adenylyl cyclase enzyme activity Oryctolagus cuniculus
Mn2+ may replace Mg2+ Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Oryctolagus cuniculus
-
renal cortex isoform AC5 is the major adenylyl cyclase isoform in the cortex of the kidney Oryctolagus cuniculus
-
renal medulla
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Oryctolagus cuniculus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC5 isoform Oryctolagus cuniculus
adenylyl cyclase
-
 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
Calmodulin
-
 Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000006
-
 2'(3')-O-(N-methylanthraniloyl)-ITP cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000009
-
 2'(3')-O-(N-methylanthraniloyl)-ITP medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.00001
-
 2'(3')-O-(N-methylanthraniloyl)-ITPgammaS cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000013
-
 2'(3')-O-(N-methylanthraniloyl)-GTP cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000014
-
 2'(3')-O-(N-methylanthraniloyl)-ITPgammaS medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000022
-
 2'(3')-O-(N-methylanthraniloyl)-UTP cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000027
-
 2'(3')-O-(N-methylanthraniloyl)-GTPgammaS cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000029
-
 2'(3')-O-(N-methylanthraniloyl)-ITP medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.00003
-
 2'(3')-O-(N-methylanthraniloyl)-ITP cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000031
-
 2'(3')-O-(N-methylanthraniloyl)-UTP medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000032
-
 2'(3')-O-(N-methylanthraniloyl)-GTP medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000042
-
 2'(3')-O-(N-methylanthraniloyl)-GTPgammaS medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000047
-
 2'(3')-O-(N-methylanthraniloyl)-ITPgammaS cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.00005
-
 2'(3')-O-(N-methylanthraniloyl)-ITPgammaS medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000051
-
 2'(3')-O-(N-methylanthraniloyl)-CTP cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.00006
-
 2'(3')-O-(N-methylanthraniloyl)-ATPgammaS cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000061
-
 2'(3')-O-(N-methylanthraniloyl)-ATP cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000072
-
 2'(3')-O-(N-methylanthraniloyl)-CTP medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000075
-
 2'(3')-O-(N-methylanthraniloyl)-ATPgammaS medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000125
-
 2'(3')-O-(N-methylanthraniloyl)-ATP medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000468
-
 2'(3')-O-(N-methylanthraniloyl)-GTPgammaS medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000666
-
 2'(3')-O-(N-methylanthraniloyl)-GTPgammaS cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000706
-
 2'(3')-O-(N-methylanthraniloyl)-ATPgammaS cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.000872
-
 2'(3')-O-(N-methylanthraniloyl)-ATPgammaS medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.001087
-
 2'(3')-O-(N-methylanthraniloyl)-GTP cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.001249
-
 2'(3')-O-(N-methylanthraniloyl)-GTP medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.001435
-
 2'(3')-O-(N-methylanthraniloyl)-UTP medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.0015
-
 2'(3')-O-(N-methylanthraniloyl)-UTP cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.001628
-
 2'(3')-O-(N-methylanthraniloyl)-ATP cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.003115
-
 2'(3')-O-(N-methylanthraniloyl)-CTP medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.003558
-
 2'(3')-O-(N-methylanthraniloyl)-ATP medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus
0.004141
-
 2'(3')-O-(N-methylanthraniloyl)-CTP cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication Oryctolagus cuniculus