Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Derkach, K.; Shpakov, A.; Uspenskaya, Z.; Yudin, A.
    Functional characteristics of calcium-sensitive adenylyl cyclase of the infusorian Tetrahymena pyriformis (2010), Cell Tissue Biol., 4, 587-593.
No PubMed abstract available
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
cAMP the stimulatory effect of cAMP on adenylyl cyclase activity is enhanced in the presence of 0.005 mM Ca2+ and decreased in the presence of 0.1 mM Ca2+ Tetrahymena pyriformis
D-glucose the stimulatory effect of D-glucose does not change in the presence of Ca2+ and calmodulin antagonists chloropromazine, N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride Tetrahymena pyriformis
EGF the stimulatory effect of EGF on adenylyl cyclase activity is enhanced in the presence of 0.005 mM Ca2+ and decreased in the presence of 0.1 mM Ca2+ Tetrahymena pyriformis
Insulin the stimulatory effect of insulin on adenylyl cyclase is decreased to 28% in the presence of 0.1 mM Ca2+ Tetrahymena pyriformis
serotonin the stimulatory effect of serotonin on adenylyl cyclase activity (253%) is enhanced in the presence of 0.005 mM Ca2+ Tetrahymena pyriformis

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ at 0.1 mM and higher, the calcium cations inhibit the adenylyl cyclase activity Tetrahymena pyriformis

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ maximum stimulatory effect at 0.002 mM Ca2+. (increase of 387% activity). Antagonists of calmodulin, N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride, at concentrations of 0.02-0.1 mM decrease the stimulatory effect of 0.005 mM Ca2+, while at the higher concentrations inhibit it completely. Chloropromazine decreases the Ca2+-stimulated adenylyl cyclase activity only at concentrations of 0.2-1.0 mM Tetrahymena pyriformis

Organism

Organism UniProt Comment Textmining
Tetrahymena pyriformis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Tetrahymena pyriformis 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
adenylyl cyclase
-
 Tetrahymena pyriformis
ATP-pyrophosphate lyase cyclizing
-
 Tetrahymena pyriformis