Crystallization (Comment) | Organism |
---|---|
crystallized in complex with substrate and Ca2+ or Mg2+ | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | AC5 and AC6 are inhibited by Ca2+ at both sub- and supra-micromolar concentration, Ca2+ inhibits the soluble adenylate cyclase core composed of the C1 domain of AC5 and the C2 domain of AC2, at micromolar concentration Ca2+ inhibition is non-exclusive with respect to diphosphate, but at 0.1 mM Ca2+ and above inhibition appears to be exclusive with respect to diphosphate | Homo sapiens | |
diphosphate | non-competitive inhibitor with respect to ATP | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requires Mg2+ or Mn2+ as cofactors | Homo sapiens | |
Mn2+ | requires Mg2+ or Mn2+ as cofactors | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC5 | isoform | Homo sapiens |
AC6 | isoform | Homo sapiens |
type V adenylyl cyclase | isoform | Homo sapiens |
type VI adenylyl cyclase | isoform | Homo sapiens |