Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | activated by 0.001 mM forskolin, coapplication of geldanamycin (0.1-10 nM) effectively suppresses the increase in forskolin-activated adenylate cyclase activation by 56% | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arginine-vasopressin | - |
Homo sapiens | |
Oxytocin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SK-N-SH cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type I adenylate cyclase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000034 | - |
- |
Homo sapiens | Oxytocin | |
0.000022 | - |
- |
Homo sapiens | arginine-vasopressin |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in SK-N-SH human neuroblastoma cells, morphine significantly increases RNA transcript and protein levels of type I adenylate cyclase | up |