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Literature summary for 4.6.1.1 extracted from

  • Marquez, B.; Suarez, S.S.
    Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation (2008), Reprod. Fertil. Dev., 20, 247-252.
    View publication on PubMed
Search for more literature for 4.6.1.1

Protein Variants

Protein Variants Comment Organism
additional information sperm from Sacy null mice are immotile or weakly motile, but their motility is activated by the cAMP analogues N6,2'-O-dibutyryladenosine 3',5'-cyclic monophosphate and adenosine 3',5'-cyclic monophosphate acetoxymethyl ester activated motility. Ca2+ cannot substitute for cAMP analogues in activating motility in the mutant, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates the soluble adenylyl cyclase Mus musculus
HCO3- stimulates the soluble adenylyl cyclase Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Mus musculus soluble adenylyl cyclase is an essential component of cAMP-signalling cascades that activate sperm motility and capacitate sperm, but soluble adenylyl cyclase does not have a direct effect on hyperactivation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C0T9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sperm
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information soluble adenylyl cyclase is an essential component of cAMP-signalling cascades that activate sperm motility and capacitate sperm, but soluble adenylyl cyclase does not have a direct effect on hyperactivation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
SACY
-
 Mus musculus
soluble adenylyl cyclase
-
 Mus musculus