Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no activation of the soluble isozyme by the transmembrane isozyme-specific activator forskolin | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
the testis isozyme is located in the Sacytm1Lex locus, sAC transcripts in brain use an alternate start site than the testis isozyme transcripts | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genetic deletion of the second through fourth coding exons in Sacytm1Lex/Sacytm1Lex knockout mice, deficient in sperm soluble isozyme, results in a male sterile phenotype, the soluble isozymes from brain are not affected, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxyestradiol | a catechol estrogen and sAC-selective inhibitor | Rattus norvegicus | |
KH7 | sAC-specific inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | soluble isozymes | Rattus norvegicus | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
about, brain and testis cytosolic isozymes | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Rattus norvegicus | soluble isozymes sAC play a unique function in male germ cells, overview | 3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cytosolic brain isozyme | Rattus norvegicus | - |
additional information | tissue specific expression of cytosolic isozymes, overview | Rattus norvegicus | - |
sperm | cytosolic testis isozyme, not detected in brain | Rattus norvegicus | - |
testis | cytosolic testis isozyme, not detected in brain | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
soluble isozyme sAC activity from Sacytm1Lex/Sacytm1Lex brains, somatic sAC activity in brain is lower than activity in testis, overview | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | soluble isozymes sAC play a unique function in male germ cells, overview | Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | epitope mapping of cytosolic isozymes, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
sAC | - |
Rattus norvegicus |
soluble adenylyl cyclase | - |
Rattus norvegicus |