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Literature summary for 4.6.1.1 extracted from

  • Farrell, J.; Ramos, L.; Tresguerres, M.; Kamenetsky, M.; Levin, L.R.; Buck, J.
    Somatic soluble adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex knockout mice (2008), PLoS ONE, 3, e3251.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation of the soluble isozyme by the transmembrane isozyme-specific activator forskolin Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
the testis isozyme is located in the Sacytm1Lex locus, sAC transcripts in brain use an alternate start site than the testis isozyme transcripts Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information genetic deletion of the second through fourth coding exons in Sacytm1Lex/Sacytm1Lex knockout mice, deficient in sperm soluble isozyme, results in a male sterile phenotype, the soluble isozymes from brain are not affected, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxyestradiol a catechol estrogen and sAC-selective inhibitor Rattus norvegicus
KH7 sAC-specific inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol soluble isozymes Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
about, brain and testis cytosolic isozymes Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus soluble isozymes sAC play a unique function in male germ cells, overview 3',5'-cyclic-AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cytosolic brain isozyme Rattus norvegicus
-
additional information tissue specific expression of cytosolic isozymes, overview Rattus norvegicus
-
sperm cytosolic testis isozyme, not detected in brain Rattus norvegicus
-
testis cytosolic testis isozyme, not detected in brain Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
soluble isozyme sAC activity from Sacytm1Lex/Sacytm1Lex brains, somatic sAC activity in brain is lower than activity in testis, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?
ATP soluble isozymes sAC play a unique function in male germ cells, overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?

Subunits

Subunits Comment Organism
More epitope mapping of cytosolic isozymes, overview Rattus norvegicus

Synonyms

Synonyms Comment Organism
sAC
-
Rattus norvegicus
soluble adenylyl cyclase
-
Rattus norvegicus