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Literature summary for 4.6.1.1 extracted from

  • Ristori, C.; Ferretti, M.E.; Pavan, B.; Cervellati, F.; Casini, G.; Catalani, E.; Dal Monte, M.; Biondi, C.
    Adenylyl cyclase/cAMP system involvement in the antiangiogenic effect of somatostatin in the retina. Results from transgenic mice (2008), Neurochem. Res., 33, 1247-1255.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
additional information in hypoxia isozyme ACVII expression is enhanced in wild-type retinas and it is further increased in sst2-lacking retinas, whereas in sst2 overexpressing retinas the increase of ACVII is lower than in wild-type retinas, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis of isozymes ACI-ACIX in wild-type and hypoxic retinas by real time PCR, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of adenylyl cyclase, especially of isozyme ACVII, is involved in somatostatin anti-angiogenic actions Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Mus musculus inhibition of adenylyl cyclase and cAMP production is involved in somatostatin anti-angiogenic actions, neoangiogenesis is a response to retinal hypoxia that is inhibited by somatostatin through its subtype 2 receptor, sst2, hypoxia increases AC responsiveness, especially of isozyme ACVII, in wild-type retinas and in retinas lacking sst2, but not in sst2-overexpressing retinas, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 isozymes ACI-ACIX
-

Source Tissue

Source Tissue Comment Organism Textmining
retina localization of isozyme ACVII in photoreceptorouter segments, the outer plexiform layer, the inner plexiform layer and the ganglion cell layer Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information inhibition of adenylyl cyclase and cAMP production is involved in somatostatin anti-angiogenic actions, neoangiogenesis is a response to retinal hypoxia that is inhibited by somatostatin through its subtype 2 receptor, sst2, hypoxia increases AC responsiveness, especially of isozyme ACVII, in wild-type retinas and in retinas lacking sst2, but not in sst2-overexpressing retinas, overview Mus musculus ?
-
 ?