Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | Ca2+ stimulates transmembrane isozyme AC8 via calmodulin | Rattus norvegicus | |
Calmodulin | stimulates AC8 which shows a dis-inhibitory activation mechanism, Ca2+ stimulates transmembrane isozymes AC1 and AC8 via calmodulin, and inhibits AC5 and AC6 directly | Mus musculus |
Cloned (Comment) | Organism |
---|---|
overexpression of untagged AC8 and C-terminally HA-tagged AC8 in HEK293 cells, co-expression of HA-tagged AC8, myc-tagged Orai1 and untagged STIM1 in membranes, and co-expression of CFP-tagged AC8, YFP-tagged STIM1 and myc-tagged Orai1 with co-localization at the plasma membrane | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ stimulates transmembrane isozymes AC1 and AC8 via calmodulin, and inhibits AC5 and AC6 directly | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | nine transmembrane AC isozymes, of which four are sensitive to Ca2+ | Mus musculus | 16020 | - |
membrane | transmembrane AC isozymes, some of which are sensitive to Ca2+ | Rattus norvegicus | 16020 | - |
additional information | close apposition between the enzyme and CCE channels | Mus musculus | - |
- |
additional information | close apposition between the enzyme and CCE channels | Rattus norvegicus | - |
- |
plasma membrane | AC8 is confined to lipid raft microdomains of the plasma membrane. AC8, Orai1 and STIM1 are co-localized in lipid raft domains of the plasma membrane | Mus musculus | 5886 | - |
plasma membrane | AC8 is confined to lipid raft microdomains of the plasma membrane. AC8, Orai1 and STIM1 are co-localized in lipid raft domains of the plasma membrane | Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ stimulates transmembrane isozyme AC8 via calmodulin, capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, AC8 shows a dis-inhibitory activation mechanism | Rattus norvegicus | |
Ca2+ | stimulates Ca2+ stimulates transmembrane isozymes AC1 and AC8 via calmodulin, and inhibits AC5 and AC6 directly, capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, AC8 shows a dis-inhibitory activation mechanism | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Rattus norvegicus | capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Mus musculus | the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ | ? | - |
? | |
additional information | Rattus norvegicus | the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | P40146 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MIN-6 cell | the insulin-secreting cells, derived from in vivo immortalized insulin-secreting pancreatic beta cells, are endogenously expressing Ca2+-sensitive AC isoforms | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | capacitative Ca2+ entry via plasma membrane pore-forming component Orai1, i.e. Ca2+ release-activated Ca2+ modulator 1 or CRACM1, and stromal interacting molecule 1, STIM1, regulates adenylyl cyclase type 8, other modes of Ca2+ entry, including those activated by arachidonate and the ionophore ionomycin, are ineffective, detailed overview | Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ | Mus musculus | ? | - |
? | |
additional information | the complexity of signalling by the ubiquitous second messenger cAMP is enhanced by multiple regulatory susceptibilities of its synthesis by adenylyl cyclases and degradation by phosphodiesterases, ACs receive regulatory signals from multiple sources, such as G-proteins, protein kinases, growth factors and Ca2+ | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC8 | - |
Mus musculus |
AC8 | - |
Rattus norvegicus |
adenylyl cyclase type 8 | - |
Mus musculus |
adenylyl cyclase type 8 | - |
Rattus norvegicus |
Ca2+-calmodulin stimulated adenylyl cyclase type 8 | - |
Mus musculus |
Ca2+-calmodulin stimulated adenylyl cyclase type 8 | - |
Rattus norvegicus |