Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | leads to cAMP accumulation in C6 glioma cells expressing the mu-opioid-receptor | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in C6 glioma cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
buprenorphine | a low-efficacy partial mu-opioid agonist | Homo sapiens | |
DAMGO | a higher efficacy mu-opioid agonist | Homo sapiens | |
additional information | maximal inhibition of forskolin-stimulated adenylyl cyclase by buprenorphine and nalbuphine is increased in cells expressing regulator of G protein signaling RGS-insensitive Galphao CIGS, Galphai2 CIGS, or Galphai3 CIGS compared with their GalphaCI counterparts, but the RGS-insensitive mutation has little or no effect on the maximal inhibition by DAMGO and morphine | Homo sapiens | |
morphine | a higher efficacy mu-opioid agonist | Homo sapiens | |
nalbuphine | a low-efficacy partial mu-opioid agonist | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | - |
3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition of forskolin-stimulated adenylyl cyclase by mu-opioid recptor agonists in cells expressing different forms of G proteins, overview | Homo sapiens |