Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Rattus norvegicus | adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, is involved in cAMP signalling in the pituitary gland | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Rattus norvegicus | the pituitary adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, a member of the 7-transmembrane domain, group 2 G-protein coupled receptor family, modulate neurotransmission and neurotrophic actions, its activation is pronociceptive. Blockade of the PAC1-R/PACAP complex by PACAP 6-38, a PAC1-R antagonist, can effectively attenuate thermal hyperalgesia and mechanical allodynia associated with inflammatory and neuropathic pain states, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Rattus norvegicus | - |
pituitary gland | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, is involved in cAMP signalling in the pituitary gland | Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | the pituitary adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, a member of the 7-transmembrane domain, group 2 G-protein coupled receptor family, modulate neurotransmission and neurotrophic actions, its activation is pronociceptive. Blockade of the PAC1-R/PACAP complex by PACAP 6-38, a PAC1-R antagonist, can effectively attenuate thermal hyperalgesia and mechanical allodynia associated with inflammatory and neuropathic pain states, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Rattus norvegicus |
adenylate cyclase 1 | - |
Rattus norvegicus |