Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Davis-Taber, R.; Baker, S.; Lehto, S.G.; Zhong, C.; Surowy, C.S.; Faltynek, C.R.; Scott, V.E.; Honore, P.
    Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states (2008), J. Pain, 9, 449-456.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, is involved in cAMP signalling in the pituitary gland 3',5'-cyclic-AMP + diphosphate
-
?
additional information Rattus norvegicus the pituitary adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, a member of the 7-transmembrane domain, group 2 G-protein coupled receptor family, modulate neurotransmission and neurotrophic actions, its activation is pronociceptive. Blockade of the PAC1-R/PACAP complex by PACAP 6-38, a PAC1-R antagonist, can effectively attenuate thermal hyperalgesia and mechanical allodynia associated with inflammatory and neuropathic pain states, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
Rattus norvegicus
-
pituitary gland
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?
ATP adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, is involved in cAMP signalling in the pituitary gland Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?
additional information the pituitary adenylate cyclase-activating polypeptide type 1 receptor, PAC1-R, a member of the 7-transmembrane domain, group 2 G-protein coupled receptor family, modulate neurotransmission and neurotrophic actions, its activation is pronociceptive. Blockade of the PAC1-R/PACAP complex by PACAP 6-38, a PAC1-R antagonist, can effectively attenuate thermal hyperalgesia and mechanical allodynia associated with inflammatory and neuropathic pain states, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
AC1
-
Rattus norvegicus
adenylate cyclase 1
-
Rattus norvegicus