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Literature summary for 4.6.1.1 extracted from

  • Moulder, K.L.; Jiang, X.; Chang, C.; Taylor, A.A.; Benz, A.M.; Conti, A.C.; Muglia, L.J.; Mennerick, S.
    A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing (2008), J. Neurosci., 28, 5159-5168.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin increases the number of active synapses Mus musculus
forskolin increases the number of active synapses Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information in cells from mice doubly deficient in isozymes AC1 and AC8, the baseline percentage of active synapses is only modestly reduced compared with wild-type synapses, and forskolin unsilencing is similar in the two genotypes, but after strong presynaptic silencing, recovery of normal function is strongly inhibited in AC1/AC8-deficient synapses, the entire recovery phenotype of the double null is reproduced in AC8-deficient but not in AC1-deficient cells, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
synapse
-
 Mus musculus 45202
-
synapse
-
 Rattus norvegicus 45202
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ isozymes AC1 and AC8 are the major Ca2+-sensitive AC isoforms, generally ubiquitous role of Ca2+ in the induction of activity-dependent synaptic plasticity Mus musculus
Ca2+ isozymes AC1 and AC8 are the major Ca2+-sensitive AC isoforms, generally ubiquitous role of Ca2+ in the induction of activity-dependent synaptic plasticity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Rattus norvegicus Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview. But AC8 plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Mus musculus
-
hippocampus
-
 Rattus norvegicus
-
neuron
-
 Mus musculus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview. But AC8 plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Mus musculus
AC1
-
 Rattus norvegicus
AC8
-
 Mus musculus
AC8
-
 Rattus norvegicus
adenylyl cyclase 1
-
 Mus musculus
adenylyl cyclase 1
-
 Rattus norvegicus
adenylyl cyclase 8
-
 Mus musculus
adenylyl cyclase 8
-
 Rattus norvegicus
Ca2+-dependent adenylyl cyclase
-
 Mus musculus
Ca2+-dependent adenylyl cyclase
-
 Rattus norvegicus