Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | netrin-1 does not alter cAMP levels in axons attracted by this cue | Rattus norvegicus | |
additional information | netrin-1 does not alter cAMP levels in axons attracted by this cue | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of sAC knock-out mice containing an internal ribosome entry site-LacZ/neomycin cassette that replaces exons 2-4, deleting sequence encoding a portion of the C1 domain of sAC, the C1 domain combines with C2 to form the cyclase catalytic domain. RNA transcription proceeds through the inserted IRES-LacZ/neomycin cassette and mRNAencoding C2 is produced, but not the C1 region in testis of adult sAC-null mice, but due to the frameshift of the transgene intro the C2 portions of sAC are not translated and neither sAC protein nor its activity are detectable in testis and spermatozoa of knock-out animals, overview. sAC-null mice do not exhibit any obvious neurological deficits | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | netrin-1 does not alter cAMP levels in axons attracted by this cue | Mus musculus | |
additional information | netrin-1 does not alter cAMP levels in axons attracted by this cue | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Rattus norvegicus | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Mus musculus | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Rattus norvegicus | netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 | ? | - |
? | |
additional information | Mus musculus | netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8C0T9 | - |
- |
Rattus norvegicus | Q9Z286 | pregnant Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | E15 Sprague-Dawley rat embryos | Rattus norvegicus | - |
neuron | - |
Mus musculus | - |
neuron | spinal commissural neuron cultures from embryonic day 14 from pregnant Sprague-Dawley rats | Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
testis | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 | Rattus norvegicus | ? | - |
? | |
additional information | netrin-1 does not alter cAMP levels in axons attracted by this cue, and soluble adenylyl cyclase is not required for axon guidance to netrin-1 | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sAC | - |
Rattus norvegicus |
sAC | - |
Mus musculus |
soluble adenylyl cyclase | - |
Rattus norvegicus |
soluble adenylyl cyclase | - |
Mus musculus |