Cloned (Comment) | Organism |
---|---|
expressed in mpkCCDc14 cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | RNA interference knockdown of soluble adenylyl cyclase in mpkCCDc14 cells leads to a yield of about 60% knockdown of the predominant somatic soluble adenylyl cyclase isoforms of 50-53 kDa, also amiloride-sensitive Isc is inhibited to a comparable extent | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | soluble adenylyl cyclase inhibitors reduce not only basal Isc, but also Isc stimulated by two distinct agonists, forskolin and aldosterone, suggesting that soluble adenylyl cyclase activity may be regulating electrogenic Na+ transport at a site common to all pathways, soluble adenylyl cyclase inhibition blocks ATPase activity without affecting surface expression of the Na+ pump | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Rattus norvegicus | regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Rattus norvegicus | soluble adenylyl cyclase inhibition blocks ATPase activity without affecting surface expression of the Na+ pump | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q9Z286 | adult male Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | epithelial cells, both intercalated cells and principal cells | Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells, overview | Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | soluble adenylyl cyclase inhibition blocks ATPase activity without affecting surface expression of the Na+ pump | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sAC | - |
Rattus norvegicus |
soluble adenylyl cyclase | - |
Rattus norvegicus |