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Literature summary for 4.6.1.1 extracted from

  • Lai, N.C.; Tang, T.; Gao, M.H.; Saito, M.; Takahashi, T.; Roth, D.M.; Hammond, H.K.
    Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice (2008), J. Am. Coll. Cardiol., 51, 1490-1497.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
Mus musculus

Application

Application Comment Organism
pharmacology activation of cardiac adenylyl cyclase isozyme ACVI expression increases the function of the failing ischemic heart in mice, overview. Increased left ventricular ACVI content also markedly reduces mortality and increases left ventricular function after acute myocardial infarction in mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus activation of cardiac adenylyl cyclase isozyme ACVI expression increases the function of the failing ischemic heart in mice, overview 3',5'-cyclic-AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
isozyme ACVI
-

Source Tissue

Source Tissue Comment Organism Textmining
heart expression of isozyme adenylyl cyclase VI, ACVI, at the left ventricular Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
ATP activation of cardiac adenylyl cyclase isozyme ACVI expression increases the function of the failing ischemic heart in mice, overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
ACVI
-
Mus musculus
adenylyl cyclase VI
-
Mus musculus