Literature summary for 4.6.1.1 extracted from

Mann, L.; Heldman, E.; Shaltiel, G.; Belmaker, R.H.; Agam, G.
Lithium preferentially inhibits adenylyl cyclase V and VII isoforms (2008), Int. J. Neuropsychopharmacol., 11, 533-539.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
A23187	activates isozymes AC-I and AC-III	Mus musculus
forskolin	activates isozymes AC-I to AC-VIII, but not AC-IX, which contains no forskolin binding site	Mus musculus
additional information	superactivation method for the isozymes, overview	Mus musculus
SKF-82958	a D1 dopaminergic receptor agonist	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of nine membrane-bound isozymes in COS7 cells in absence of the D1 receptor	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
Li+	lithium preferentially inhibits adenylyl cyclase V and VII isoforms, moderately also isozyme AC-II, but does not inhibit Ca2+-activated isozymes AC-I and AC-VIII, it interferes with the transduction pathways mediated via isozymes AC-V and AC-IIV. The inhibitor effect is abolished for the superactivated isozyme, overview	Mus musculus
quinpirole	inhibits the enzyme via Gi protein	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	nine membrane-bound isozymes	Mus musculus	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	stimulates the Ca2+-activated isozymes	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isozymes AC-I-AC-IX	-

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus

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Release 2023.1 (January 2023)