Literature summary for 4.6.1.1 extracted from

Krishnan, V.; Graham, A.; Mazei-Robison, M.S.; Lagace, D.C.; Kim, K.S.; Birnbaum, S.; Eisch, A.J.; Han, P.L.; Storm, D.R.; Zachariou, V.; Nestler, E.J.
Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting (2008), Biol. Psychiatry, 64, 336-343.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	Ca2+/calmodulin-stimulated isozyme AC1	Mus musculus
Calmodulin	Ca2+/calmodulin-stimulated isozyme AC8	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of male and female AC1/8 double knockout mice and AC5 knockout mice. AC1/AC8 double knockout mice are hypoactive, exhibit diminished sucrose preference, and display alterations in neurotrophic signaling, generally consistent with a prodepressant phenotype. Neither line of mice display alterations in hippocampal cell proliferation, but altered BDNF signaling, phenotypes, overview	Mus musculus
additional information	construction of male and female AC1/8 double knockout mice. AC1/AC8 double knockout mice are hypoactive, exhibit diminished sucrose preference, and display alterations in neurotrophic signaling, generally consistent with a prodepressant phenotype. Neither line of mice display alterations in hippocampal cell proliferation, but altered BDNF signaling, phenotypes, overview	Mus musculus
additional information	construction of male and female AC5 knockout mice. AC5KO mice show striking anxiolytic and antidepressant phenotypes on standard behavioral assays, phenotype, overview	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
Ca2+	calcium-inhibited AC5 isozyme	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	Ca2+/calmodulin-stimulated isozyme AC1	Mus musculus
Ca2+	Ca2+/calmodulin-stimulated isozyme AC8	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Mus musculus	-	3',5'-cyclic-AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O88444	AC1	-
Mus musculus	P84309	AC5	-
Mus musculus	P97490	AC8	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	isozyme AC1 is abundantly expressed within limbic regions of the central nervous system	Mus musculus	-
brain	isozyme AC5 is abundantly expressed within limbic regions of the central nervous system	Mus musculus	-
brain	isozyme AC8 is abundantly expressed within limbic regions of the central nervous system	Mus musculus	-
hippocampus	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Mus musculus	3',5'-cyclic-AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
calcium-sensitive adenylyl cyclase	-	Mus musculus

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Release 2023.1 (January 2023)