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Literature summary for 4.6.1.1 extracted from

  • Li, Y.; Descorbeth, M.; Anand-Srivastava, M.B.
    Role of oxidative stress in high glucose-induced decreased expression of Gialpha proteins and adenylyl cyclase signaling in vascular smooth muscle cells (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H2845-H2854.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
Rattus norvegicus
GSalpha proteins mediate stimulation of the adenylyl cyclase in case of hyperglycemia Rattus norvegicus
GTPgammaS stimulates the enzyme in hyperglycemic and control vascular smooth muscle cells Rattus norvegicus
NaF
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information oxidative stress decreases the enzyme stimulation through GTPgammaS, GSalpha proteins, and hormones, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus the enzyme is one of the signal transducing systems implicated in the regulation of the cardiovascular system and plays a role in signaling in vascular smooth muscle cells, which is decreased by oxidative stress, induced by high glucose, along with the expression of Gialpha proteins, overview 3',5'-cyclic-AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
A10 cell vascular smooth muscle cell line Rattus norvegicus
-
aorta
-
Rattus norvegicus
-
vascular smooth muscle cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?
ATP the enzyme is one of the signal transducing systems implicated in the regulation of the cardiovascular system and plays a role in signaling in vascular smooth muscle cells, which is decreased by oxidative stress, induced by high glucose, along with the expression of Gialpha proteins, overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus