Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | Ca2+/calmodulin enhance cAMP production through AC9 | Mus musculus | |
additional information | phosphorylation of a C-terminally located threonine residue increases activity of AC2 in intact HEK-293 cells | Homo sapiens |
Application | Comment | Organism |
---|---|---|
analysis | technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression | Mus musculus |
analysis | technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression | Homo sapiens |
analysis | technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression | Rattus norvegicus |
analysis | technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression | Macaca sp. |
Cloned (Comment) | Organism |
---|---|
AC9 | Mus musculus |
HEK-293 cells stably transfected with AC9 | Homo sapiens |
HEK-293 cells stably transfected with rat AC2 cDNA | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | addition of Ca2+ to cells which have been depleted of intracellular Ca2+ markedly suppress cAMP synthesis by AC9 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cis-Golgi network | AC9 | Homo sapiens | 5801 | - |
cytoplasm | - |
Macaca sp. | 5737 | - |
endoplasmic reticulum | AC9 | Mus musculus | 5783 | - |
endoplasmic reticulum | AC9 | Homo sapiens | 5783 | - |
additional information | in AtT20 cells AC9 mainly in irregular discrete punctae which are distinct from lysosomes, early endosomes or tubulovesicular endosomes, AC9 present in the cis-Golgi network | Mus musculus | - |
- |
additional information | in SH-SY5Y cells AC9 mainly in irregular discrete punctae which are distinct from lysosomes, early endosomes or tubulovesicular endosomes | Homo sapiens | - |
- |
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+/calmodulin enhance cAMP production through AC9 | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
130000 | - |
immunoblotting | Rattus norvegicus |
190000 | - |
AC9, Western blot analysis | Homo sapiens |
192000 | - |
AC9, immunoblotting | Mus musculus |
192000 | - |
AC9, Western blot analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Macaca sp. | - |
- |
- |
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anterior lobe | AC2 | Rattus norvegicus | - |
brain | AC1, pre-synaptic localisation in mossy fibres | Macaca sp. | - |
brain | AC9 | Mus musculus | - |
granule cell | AC9 | Homo sapiens | - |
HEK-293 cell | AC2, AC9 | Homo sapiens | - |
hippocampus | AC9 | Rattus norvegicus | - |
hypothalamic nucleus | AC2 | Rattus norvegicus | - |
additional information | AtT20 cell and secretory granules, AC9 present | Mus musculus | - |
pituitary gland tumor cell | AC9 | Mus musculus | - |
posterior lobe | AC2 | Rattus norvegicus | - |
SH-SY5Y cell | AC9 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Homo sapiens | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Rattus norvegicus | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Mus musculus C57BL/6 | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Macaca sp. |
AC2 | - |
Homo sapiens |
AC2 | - |
Rattus norvegicus |
AC9 | - |
Mus musculus |
AC9 | - |
Homo sapiens |
AC9 | - |
Rattus norvegicus |
adenylyl cyclase 9 | - |
Mus musculus |