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Literature summary for 4.6.1.1 extracted from

  • Antoni, F.A.; Wiegand, U.K.; Black, J.; Simpson, J.
    Cellular localisation of adenylyl cyclase: a post-genome perspective (2006), Neurochem. Res., 31, 287-295.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin Ca2+/calmodulin enhance cAMP production through AC9 Mus musculus
additional information phosphorylation of a C-terminally located threonine residue increases activity of AC2 in intact HEK-293 cells Homo sapiens

Application

Application Comment Organism
analysis technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression Mus musculus
analysis technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression Homo sapiens
analysis technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression Rattus norvegicus
analysis technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression Macaca sp.

Cloned(Commentary)

Cloned (Comment) Organism
AC9 Mus musculus
HEK-293 cells stably transfected with AC9 Homo sapiens
HEK-293 cells stably transfected with rat AC2 cDNA Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ addition of Ca2+ to cells which have been depleted of intracellular Ca2+ markedly suppress cAMP synthesis by AC9 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cis-Golgi network AC9 Homo sapiens 5801
-
cytoplasm
-
Macaca sp. 5737
-
endoplasmic reticulum AC9 Mus musculus 5783
-
endoplasmic reticulum AC9 Homo sapiens 5783
-
additional information in AtT20 cells AC9 mainly in irregular discrete punctae which are distinct from lysosomes, early endosomes or tubulovesicular endosomes, AC9 present in the cis-Golgi network Mus musculus
-
-
additional information in SH-SY5Y cells AC9 mainly in irregular discrete punctae which are distinct from lysosomes, early endosomes or tubulovesicular endosomes Homo sapiens
-
-
plasma membrane
-
Homo sapiens 5886
-
plasma membrane
-
Rattus norvegicus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+/calmodulin enhance cAMP production through AC9 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
immunoblotting Rattus norvegicus
190000
-
AC9, Western blot analysis Homo sapiens
192000
-
AC9, immunoblotting Mus musculus
192000
-
AC9, Western blot analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Macaca sp.
-
-
-
Mus musculus
-
C57BL/6 mice
-
Mus musculus C57BL/6
-
C57BL/6 mice
-
Rattus norvegicus
-
male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
anterior lobe AC2 Rattus norvegicus
-
brain AC1, pre-synaptic localisation in mossy fibres Macaca sp.
-
brain AC9 Mus musculus
-
granule cell AC9 Homo sapiens
-
HEK-293 cell AC2, AC9 Homo sapiens
-
hippocampus AC9 Rattus norvegicus
-
hypothalamic nucleus AC2 Rattus norvegicus
-
additional information AtT20 cell and secretory granules, AC9 present Mus musculus
-
pituitary gland tumor cell AC9 Mus musculus
-
posterior lobe AC2 Rattus norvegicus
-
SH-SY5Y cell AC9 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cAMP + diphosphate
-
?
ATP
-
Homo sapiens 3',5'-cAMP + diphosphate
-
?
ATP
-
Rattus norvegicus 3',5'-cAMP + diphosphate
-
?
ATP
-
Mus musculus C57BL/6 3',5'-cAMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
AC1
-
Macaca sp.
AC2
-
Homo sapiens
AC2
-
Rattus norvegicus
AC9
-
Mus musculus
AC9
-
Homo sapiens
AC9
-
Rattus norvegicus
adenylyl cyclase 9
-
Mus musculus