Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Carbachol | carbachol-induced capacitative Ca2+ entry clearly stimulates AC8-mediated cAMP production at the single-cell level | Homo sapiens | |
isoprenaline | - |
Homo sapiens | |
additional information | prior activation of AC8 is not strictly necessary to observe Ca2+-driven cAMP dynamics. Nevertheless, amplitude of the transients is enhanced when AC8 is stimulated | Homo sapiens | |
prostaglandin E1 | - |
Homo sapiens | |
thapsigargin | thapsigargin-induced capacitative Ca2+ entry clearly stimulates AC8-mediated cAMP production at the single-cell level | Homo sapiens |
Application | Comment | Organism |
---|---|---|
additional information | AC8 acts as a low-pass filter for high-frequency Ca2+ events, enhancing the regulatory options available to this signalling pathway | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | during artificial or agonist-induced Ca2+ oscillations, periodic changes in cAMP that depended upon Ca2+ stimulation of AC8 with subsequent PKA-mediated phosphodiesterase 4 activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC8 | - |
Homo sapiens |
type 8 adenylyl cyclase | - |
Homo sapiens |