Literature summary for 4.6.1.1 extracted from

Perez Vidakovics, M.L.; Lamberti, Y.; van der Pol, W.L.; Yantorno, O.; Rodriguez, M.E.
Adenylate cyclase influences filamentous haemagglutinin-mediated attachment of Bordetella pertussis to epithelial alveolar cells (2006), FEMS Immunol. Med. Microbiol., 48, 140-147.

Search for more literature for 4.6.1.1

Application

Application	Comment	Organism
additional information	ACT enhances the adhesive functions of filamentous haemagglutinin and modifies the performance of the filamentous haemagglutinin heparin-inhibitable carbohydrate binding site	Bordetella pertussis

Protein Variants

Protein Variants	Comment	Organism
additional information	mutants lacking either filamentous haemagglutinin or ACT (strain Bp3183) show significantly decreased adherence to human epithelial respiratory cells, lack of ACT does not affect filamentous haemagglutinin cellular expression, attachment level of the ACT-deficient mutant to A549 cells is not affected by the presence of heparin	Bordetella pertussis

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	antibodies against ACT fail to block Bordetella pertussis attachment to human A549 cells	Bordetella pertussis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
outer membrane	-	Bordetella pertussis	19867	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Bordetella pertussis

Organism

Organism	UniProt	Comment	Textmining
Bordetella pertussis	-	-	-
Bordetella pertussis Tohama I	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
ACT	-	Bordetella pertussis
adenylate cyclase toxin	-	Bordetella pertussis

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Release 2023.1 (January 2023)