Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bicarbonate | 50 mM stimulate sAC activity 2fold | Strongylocentrotus purpuratus | |
forskolin | stimulates tmAC activity 1.6fold | Strongylocentrotus purpuratus | |
NaF | stimulates tmAC activity 2.9fold | Strongylocentrotus purpuratus |
Application | Comment | Organism |
---|---|---|
additional information | both sAC and tmACs participate in the sperm acrosome reaction and sperm motility | Strongylocentrotus purpuratus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',5'-dideoxyadenosine | inhibits forskolin induced tmAC stimulation at 0.15 mM | Strongylocentrotus purpuratus | |
2-hydroxyestradiol | selective sAC inhibitor, inhibits the jelly induced acrosome reaction by 30% as well as the increase in cAMP levels by 42% | Strongylocentrotus purpuratus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | present in the head, acrosomal and mitochondrial area and in flagellar membranes of sperm | Strongylocentrotus purpuratus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | - |
Strongylocentrotus purpuratus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
75000 | - |
degraded sAC, Western blot analysis | Strongylocentrotus purpuratus |
190000 | - |
Western blot analysis | Strongylocentrotus purpuratus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Strongylocentrotus purpuratus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially purified | Strongylocentrotus purpuratus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | flagellum | Strongylocentrotus purpuratus | - |
sperm | both tmAC and sAC present, presence of more than one tmAC isoform in sea urchin sperm | Strongylocentrotus purpuratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Strongylocentrotus purpuratus | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
particulate adenylyl cyclase | - |
Strongylocentrotus purpuratus |
sAC | - |
Strongylocentrotus purpuratus |
soluble adenylyl cyclase | - |
Strongylocentrotus purpuratus |
tmAC | - |
Strongylocentrotus purpuratus |
transmembrane adenylyl cyclase | - |
Strongylocentrotus purpuratus |