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Literature summary for 4.6.1.1 extracted from

  • Paunescu, T.G.; Da Silva, N.; Russo, L.M.; McKee, M.; Lu, H.A.; Breton, S.; Brown, D.
    Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells (2008), Am. J. Physiol. Renal Physiol., 294, F130-F138.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
acetazolamide when apical membrane insertion of the vacuolar proton pumping ATPase is stimulated by treatment with acetazolamide, sAC is also concentrated in the apical membrane of A-intercalated cells Rattus norvegicus
bicarbonate
-
 Rattus norvegicus

Application

Application Comment Organism
medicine sAC and the vacuolar proton pumping ATPase have a close association, may be part of a protein complex that is involved in regulating renal distal proton secretion Mus musculus
medicine sAC and the vacuolar proton pumping ATPase have a close association, may be part of a protein complex that is involved in regulating renal distal proton secretion Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm apical domain of type A-intercalated cells Rattus norvegicus 5737
-
microvillus apical domain of type A-intercalated cells Rattus norvegicus 5902
-
plasma membrane sAC and the vacuolar proton pumping ATPase colocalize on or close to the apical plasma membrane in B1 vacuolar proton pumping ATPase deficient mice, colocalization does not require the B1 isoform Mus musculus 5886
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 immunoprecipitation, splice variant of the protein, which is the major functional sAC variant in many tissues Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 adult male C57BL6 mice and B1 vacuolar proton pumping ATPase deficient mice
-
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney 50 kDa splice variant and mRNA coding for full-length sAC Rattus norvegicus
-
kidney collecting duct, apical domain of type A-intercalated cells Mus musculus
-
renal epithelium in all intercalated cells, sAC and vacuolar proton pumping ATPase show considerable overlap under basal conditions, but sAC is also found in other cellular locations in the absence of vacuolar proton pumping ATPase. In type A-intercalated cells, both sAC and vacuolar proton pumping ATPase are apically and subapically located, whereas in type B-intercalated cells, significant basolateral colocalization of sAC and the vacuolar proton pumping ATPase is seen Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
sAC
-
 Mus musculus
sAC
-
 Rattus norvegicus
soluble adenylyl cyclase
-
 Mus musculus
soluble adenylyl cyclase
-
 Rattus norvegicus