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Literature summary for 4.6.1.1 extracted from

  • Steegborn, C.; Litvin, T.N.; Hess, K.C.; Capper, A.B.; Taussig, R.; Buck, J.; Levin, L.R.; Wu, H.
    A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen (2005), J. Biol. Chem., 280, 31754-31759.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Crystallization (Commentary)

Crystallization (Comment) Organism
complex with 2-hydroxyestradiol and alpha/beta-methylene-ATP, 20-3 A resolution Arthrospira platensis

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxyestradiol IC50 of about 2 microM Arthrospira platensis
2-hydroxyestradiol reversible inhibition of recombinant soluble enzyme in dose dependent manner, IC50 in low micromolar range, trans-membrane enzyme VII IC50 of about 2 microM Homo sapiens
2-hydroxyestrone reversible inhibition of recombinant soluble enzyme in dose dependent manner, IC50 in low micromolar range Homo sapiens
4-hydroxyestradiol
-
 Arthrospira platensis
4-hydroxyestradiol reversible inhibition of recombinant soluble enzyme in dose dependent manner, IC50 in low micromolar range Homo sapiens
additional information not inhibitory: estrone and estrogen Homo sapiens

Organism

Organism UniProt Comment Textmining
Arthrospira platensis
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Arthrospira platensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens cAMP + diphosphate
-
 ?
ATP
-
 Arthrospira platensis cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
cyaC
-
 Arthrospira platensis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
 IC50 of about 2 microM Arthrospira platensis 2-hydroxyestradiol
0.002
-
 reversible inhibition of recombinant soluble enzyme in dose dependent manner, IC50 in low micromolar range, trans-membrane enzyme VII IC50 of about 2 microM Homo sapiens 2-hydroxyestradiol