Literature summary for 4.6.1.1 extracted from

Muhia, D.K.; Swales, C.A.; Eckstein-Ludwig, U.; Saran, S.; Polley, S.D.; Kelly, J.M.; Schaap, P.; Krishna, S.; Baker, D.A.
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum (2003), J. Biol. Chem., 278, 22014-22022.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of splice variant 3 in Xenopus laevis, expression of splice variants 1 and 3 in Dictyostelium	Plasmodium falciparum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Plasmodium falciparum	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	very little activity in the presence of Mg2+	Plasmodium falciparum
Mn2+	maximum activity at 1 mM and 3 mM Mn2+, respectively	Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
81000	-	x * 81000, deduced from nucleotide sequence, splice variant 1	Plasmodium falciparum
108000	-	x * 108000, deduced from nucleotide sequence, splice variant 3	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Plasmodium falciparum	-	3',5'-cyclic AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	Q7Z1B9	maximal PfACalpha mRNA expression in the sexual stage	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Plasmodium falciparum	3',5'-cyclic AMP + diphosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 108000, deduced from nucleotide sequence, splice variant 3	Plasmodium falciparum
?	x * 81000, deduced from nucleotide sequence, splice variant 1	Plasmodium falciparum

Synonyms

Synonyms	Comment	Organism
adenylyl cyclase	-	Plasmodium falciparum
PfACalpha	-	Plasmodium falciparum

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Release 2023.1 (January 2023)