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Literature summary for 4.6.1.1 extracted from

  • Litvin, T.N.; Kamenetsky, M.; Zarifyan, A.; Buck, J.; Levin, L.R.
    Kinetic Properties of "Soluble" Adenylyl Cyclase. Synergism between calcium and bicarbonate (2003), J. Biol. Chem., 278, 15922-15926.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NaHCO3 10 mM, 30fold activation, half-maximal activation at 11 mM Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-sAC fusion protein in SF9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ATP substrate inhibition at high concentrations, inhibition is relieved in the presence of HCO3-, no substrate inhibition in the presence of 50 mM HCO3- Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.8
-
ATP 30°C, pH 7.5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ half-maximal activation at 0.75 mM, synergistic activation in the presence of HCO3- Homo sapiens
Mg2+ activation in the presence of HCO3- Homo sapiens
Mn2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens
-
3',5'-cyclic AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant sAC Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Homo sapiens 3',5'-cyclic AMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
sAC
-
Homo sapiens
soluble adenylyl cyclase
-
Homo sapiens