Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NaHCO3 | 10 mM, 30fold activation, half-maximal activation at 11 mM | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of GST-sAC fusion protein in SF9 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | substrate inhibition at high concentrations, inhibition is relieved in the presence of HCO3-, no substrate inhibition in the presence of 50 mM HCO3- | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.8 | - |
ATP | 30°C, pH 7.5 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | half-maximal activation at 0.75 mM, synergistic activation in the presence of HCO3- | Homo sapiens | |
Mg2+ | activation in the presence of HCO3- | Homo sapiens | |
Mn2+ | required for activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | - |
3',5'-cyclic AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant sAC | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sAC | - |
Homo sapiens |
soluble adenylyl cyclase | - |
Homo sapiens |