Literature summary for 4.6.1.1 extracted from

Lawrence, A.J.; Coote, J.G.; Kazi, Y.F.; Lawrence, P.D.; MacDonald-Fyall, J.; Orr, B.M.; Parton, R.; Riehle, M.; Sinclair, J.; Young, J.; Price, N.C.
A direct pyrophosphatase-coupled assay provides new insights into the activation of the secreted adenylate cyclase from Bordetella pertussis by calmodulin (2002), J. Biol. Chem., 277, 22289-22296.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
Calmodulin	strong activation	Bordetella pertussis

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Bordetella pertussis

General Stability

General Stability	Organism
calmodulin stablizes CyaA	Bordetella pertussis

Inhibitors

Inhibitors	Comment	Organism	Structure
EGTA	freshly activated CyaA is inhibited by EGTA at low calmodulin concentrations	Bordetella pertussis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Bordetella pertussis	-	3',5'-cyclic AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Bordetella pertussis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant CyaA	Bordetella pertussis

Storage Stability

Storage Stability	Organism
-20°C, 8 M urea, no loss of activity	Bordetella pertussis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Bordetella pertussis	3',5'-cyclic AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
adenylate cyclase toxin	-	Bordetella pertussis
CyaA	-	Bordetella pertussis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)