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Literature summary for 4.6.1.1 extracted from

  • Asbury, R.F.; Cook, G.H.; Wolff, J.
    Soluble adenylate cyclase from thyroid membranes (1978), J. Biol. Chem., 253, 5286-5292.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
guanosine 5'-(beta,gamma-imido)triphosphate activation Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Bos taurus
Chloropromazine
-
 Bos taurus
Dextran sulfate
-
 Bos taurus
Polyvinyl sulfate
-
 Bos taurus
Trifluoperazine
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3 0.4 ATP
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Bos taurus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
 sucrose density gradient centrifugation Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Bos taurus 3',5'-cAMP + diphosphate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
 up to Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 membrane-bound Bos taurus
8.3
-
 solubilized enzyme Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
7 9
-
 Bos taurus