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Literature summary for 4.6.1.1 extracted from
- Purification and characterization of adenylate cyclase from Escherichia coli K12 (1983), J. Biol. Chem., 258, 3750-3758.
General Stability
| General Stability | Organism |
|---|---|
| stabilized by ATP or at -20°C as an ammonium sulfate precipitate or in 50% glycerol | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Escherichia coli |  |
| ATP | high concentrations | Escherichia coli | |
| Ca2+ | - |
Escherichia coli | |
| Ca2+ | - |
Glutamicibacter nicotianae | |
| Co2+ | high concentrations | Escherichia coli | |
| diphosphate | - |
Escherichia coli | |
| diphosphate | - |
Glutamicibacter nicotianae | |
| GTP | - |
Escherichia coli | |
| KH2PO4 | - |
Escherichia coli | |
| KH2PO4 | - |
Glutamicibacter nicotianae | |
| NaCl | - |
Escherichia coli | |
| NaCl | - |
Glutamicibacter nicotianae | |
| nucleotides | - |
Escherichia coli | |
| nucleotides | - |
Glutamicibacter nicotianae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Escherichia coli | 5829 | - |
| cytosol | - |
Glutamicibacter nicotianae | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Escherichia coli | |
| Co2+ | - |
Glutamicibacter nicotianae | |
| Mg2+ | - |
Escherichia coli | |
| Mg2+ | - |
Glutamicibacter nicotianae | |
| Mn2+ | - |
Escherichia coli | |
| Mn2+ | - |
Glutamicibacter nicotianae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 92000 | 110000 | - |
Glutamicibacter nicotianae |
| 92000 | 110000 | gel filtration, SDS-PAGE | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Glutamicibacter nicotianae | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 32 | - |
- |
Escherichia coli |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C (NH4)2SO4 precipitate, 50% glycerol, 5 mM ATP, 3 months | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | - |
Escherichia coli | 3',5'-cAMP + diphosphate | - |
? | |
| ATP | - |
Glutamicibacter nicotianae | 3',5'-cAMP + diphosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Escherichia coli |
| 45 | - |
- |
Glutamicibacter nicotianae |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | 47 | - |
Escherichia coli |
| 35 | 47 | - |
Glutamicibacter nicotianae |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.67 | - |
ATP | - |
Escherichia coli | |
| 1.67 | - |
ATP | - |
Glutamicibacter nicotianae | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Escherichia coli |
| 8.5 | - |
- |
Glutamicibacter nicotianae |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.6 | - |
Escherichia coli |
| 8 | 8.6 | - |
Glutamicibacter nicotianae |
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