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Literature summary for 4.4.1.9 extracted from
- Modulation of cyanoalanine synthase and O-acetylserine (thiol) lyases A and B activity by beta-substituted alanyl and anion inhibitors (2002), J. Exp. Bot., 53, 439-445.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chloroalanine | uncompetitive vs. L-cysteine | Spinacia oleracea |  |
| cyanoalanine | uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. chloroalanine and L-cysteine | Spinacia oleracea | |
| homocysteine | uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. chloroalanine and L-cysteine | Spinacia oleracea | |
| KCN | uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. L-cysteine | Spinacia oleracea | |
| O-acetyl-L-serine | uncompetitive vs. O-acetyl-L-serine, noncompetitive vs. chloroalanine | Spinacia oleracea | |
| sodium thiocyanate | uncompetitive vs. O-acetyl-L-serine | Spinacia oleracea | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | - |
L-cysteine | - |
Spinacia oleracea | |
| 0.54 | - |
chloroalanine | - |
Spinacia oleracea | |
| 10.5 | - |
O-acetyl-L-serine | - |
Spinacia oleracea | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chloroalanine + sulfide | Spinacia oleracea | - |
L-cysteine + Cl- | - |
? | |
| L-cysteine + HCN | Spinacia oleracea | - |
sulfide + L-3-cyanoalanine | - |
? | |
| O-acetyl-L-serine + sulfide | Spinacia oleracea | - |
L-cysteine + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Spinacia oleracea | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Spinacia oleracea |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Spinacia oleracea | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chloroalanine + sulfide | - |
Spinacia oleracea | L-cysteine + Cl- | - |
? | |
| L-cysteine + HCN | - |
Spinacia oleracea | sulfide + L-3-cyanoalanine | - |
? | |
| O-acetyl-L-serine + sulfide | - |
Spinacia oleracea | L-cysteine + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyanoalanine synthase | - |
Spinacia oleracea |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.86 | - |
cyanoalanine | vs. O-acetyl-L-serine | Spinacia oleracea | |
| 0.87 | - |
KCN | vs. O-acetyl-L-serine | Spinacia oleracea | |
| 1.29 | - |
homocysteine | vs. O-acetyl-L-serine | Spinacia oleracea | |
| 1.45 | - |
sodium thiocyanate | vs. O-acetyl-L-serine | Spinacia oleracea | |
| 2.27 | - |
chloroalanine | vs. L-cysteine | Spinacia oleracea | |
| 2.59 | - |
KCN | vs. chloroalanine | Spinacia oleracea | |
| 5 | - |
O-acetyl-L-serine | vs. chloroalanine | Spinacia oleracea | |
| 5.93 | - |
cyanoalanine | vs. chloroalanine | Spinacia oleracea | |
| 9.04 | - |
sodium thiocyanate | vs. chloroalanine | Spinacia oleracea | |
| 9.9 | - |
homocysteine | vs. chloroalanine | Spinacia oleracea | |
| 10.1 | - |
homocysteine | vs. L-cysteine | Spinacia oleracea | |
| 15.1 | - |
sodium thiocyanate | vs. L-cysteine | Spinacia oleracea | |
| 30 | - |
cyanoalanine | vs. L-cysteine | Spinacia oleracea | |
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