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Literature summary for 4.4.1.5 extracted from
- Defence against methylglyoxal in Group A Streptococcus a role for Glyoxylase I in bacterial virulence and survival in neutrophils? (2016), Pathog. Dis., 74, ftv122 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus pyogenes | - |
- |
- |
| Streptococcus pyogenes M1T1 | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GloA | - |
Streptococcus pyogenes |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | a mutant deficient in glyoxylase I is more sensitive to methylglyoxal and also more susceptible to human neutrophil killing. Inhibition of neutrophil myeloperoxidase rescues the gloA-deficient mutant. The mutant strain is slower at disseminating into the blood in the murine model | Streptococcus pyogenes |
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