Literature summary for 4.4.1.5 extracted from

Hikita, K.; Yamada, S.; Shibata, R.; Katoh, M.; Murata, T.; Kato, K.; Tanaka, H.; Kaneda, N.
Inhibitory effect of isoflavones from Erythrina poeppigiana on the growth of HL-60 human leukemia cells through inhibition of glyoxalase I (2015), Nat. Prod. Commun., 10, 1581-1584 .

Search for more literature for 4.4.1.5

Application

Application	Comment	Organism
medicine	treatment of HL-60 cells leads to significant accumulation of substrate methylglyoxal and the caspase 3 activity of the cell lysate increases. Compound shows anti-proliferative activity against HL-60 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
isolupalbigenin	treatment of HL-60 cells leads to significant accumulation of substrate methylglyoxal and the caspase 3 activity of the cell lysate increases. Compound shows anti-proliferative activity against HL-60 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q04760	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione + methylglyoxal	-	Homo sapiens	(R)-S-lactoylglutathione	-	?

Synonyms

Synonyms	Comment	Organism
Glo1	-	Homo sapiens

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Release 2023.1 (January 2023)