Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + methylglyoxal | Mus musculus | - |
(R)-S-lactoylglutathione | - |
? | |
glutathione + methylglyoxal | Homo sapiens | - |
(R)-S-lactoylglutathione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
aorta | aortic sinus derived from apolipoprotein-E-knockout mouse on a high-fat diet for 6 months, enzyme expression is restricted to a subset of cells | Mus musculus | - |
cardiomyocyte | high expression level | Mus musculus | - |
endothelial cell | - |
Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
lymphocyte | - |
Homo sapiens | - |
macrophage | - |
Mus musculus | - |
macrophage | - |
Homo sapiens | - |
podocyte | - |
Mus musculus | - |
podocyte | - |
Homo sapiens | - |
pulmonary artery | - |
Mus musculus | - |
pulmonary artery | carotid sample derived from thromboendarterectomy | Homo sapiens | - |
smooth muscle cell | medial, high expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + methylglyoxal | - |
Mus musculus | (R)-S-lactoylglutathione | - |
? | |
glutathione + methylglyoxal | - |
Homo sapiens | (R)-S-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glo1 | - |
Mus musculus |
Glo1 | - |
Homo sapiens |
glyoxalase I | - |
Mus musculus |
glyoxalase I | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | increased methylglyoxal levels, resulting from decreased enzyme activity, induce apoptosis in fully differentiated podocytes, as well as in endothelial cells and macrophages in hypoxic regions of atherosclerotic arteries | Mus musculus |
malfunction | increased methylglyoxal levels, resulting from decreased enzyme activity, induce apoptosis in fully differentiated podocytes, as well as in endothelial cells and macrophages in hypoxic regions of atherosclerotic arteries | Homo sapiens |
metabolism | the glyoxalase system is composed of glyoxalase I, glyoxalase II, and glutathione as cofactor | Mus musculus |
metabolism | the glyoxalase system is composed of glyoxalase I, glyoxalase II, and glutathione as cofactor | Homo sapiens |
physiological function | the enzyme is part of the glyoxylate system, whose function is to detoxify reactive metabolites, which mainly accumulate during hyperglycaemic metabolism, major substrate is methylglyoxal. The mean glyoxalase I activity of atherosclerotic tissue from aortic and coronary artery samples is significantly reduced compared with healthy tissue derived from the same vessel, indicating a role for glyoxalase I in atherogenesis, the enzyme plays a role in inflammatory response, hypertension, and diabetic microvascular complications, overview | Mus musculus |
physiological function | the enzyme is part of the glyoxylate system, whose function is to detoxify reactive metabolites, which mainly accumulate during hyperglycaemic metabolism, major substrate is methylglyoxal. The mean glyoxalase I activity of atherosclerotic tissue from aortic and coronary artery samples is significantly reduced compared with healthy tissue derived from the same vessel, indicating a role for glyoxalase I in atherogenesis, the enzyme plays a role in inflammatory response, hypertension, and diabetic microvascular complications, overview | Homo sapiens |