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Literature summary for 4.4.1.5 extracted from

  • More, S.S.; Vince, R.
    Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors (2009), J. Med. Chem., 52, 4650-4656.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-3-[([(2R)-3-[(4-bromobenzyl)sulfanyl]-1-[(carboxymethyl)amino]-1-oxopropan-2-yl]carbamoyl)amino]propanoic acid
-
Homo sapiens
(S)-4-bromobenzyl glutathione potent Glx-I inhibitor Homo sapiens
NH2-gamma-Gla[-Glu(CON(OH)-4-bromophenyl)Gly-OH]-OH
-
Homo sapiens
NH2-gamma-Glu[-D-Glu(CON(OH)-4-bromophenyl)-Gly-OH]-OH
-
Homo sapiens
NH2-gamma-Glu[-Dab(N-(4-bromobenzoyl)-N'-hydroxyl)-Gly-OH]-OH
-
Homo sapiens
NH2-gamma-Glu[-Glu(CON(OH)-4-bromophenyl)-Gly-OH]-OH
-
Homo sapiens
zinc (2S)-2-amino-3-([(3R)-3-([[(4-bromophenyl)(hydroxy)carbamoyl]sulfanyl]methyl)-4-[(carboxylatomethyl)amino]-4-oxobutanoyl]amino)propanoate
-
Homo sapiens
zinc (2S)-2-amino-3-[([(2R)-3-[[(4-bromophenyl)(hydroxy)carbamoyl]sulfanyl]-1-[(carboxylatomethyl)amino]-1-oxopropan-2-yl]carbamoyl)amino]propanoate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + glutathione
-
Homo sapiens (R)-S-lactoylglutathione
-
?

Synonyms

Synonyms Comment Organism
Glx-I
-
Homo sapiens
glyoxalase I
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
glutathione
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000000123
-
NH2-gamma-Glu[-Dab(N-(4-bromobenzoyl)-N'-hydroxyl)-Gly-OH]-OH
-
Homo sapiens
0.00000166
-
NH2-gamma-Glu[-D-Glu(CON(OH)-4-bromophenyl)-Gly-OH]-OH
-
Homo sapiens
0.00000617
-
NH2-gamma-Glu[-Glu(CON(OH)-4-bromophenyl)-Gly-OH]-OH
-
Homo sapiens
0.0000326
-
NH2-gamma-Gla[-Glu(CON(OH)-4-bromophenyl)Gly-OH]-OH
-
Homo sapiens
0.00115
-
zinc (2S)-2-amino-3-([(3R)-3-([[(4-bromophenyl)(hydroxy)carbamoyl]sulfanyl]methyl)-4-[(carboxylatomethyl)amino]-4-oxobutanoyl]amino)propanoate 0.05 M phosphate buffer pH 6.6, 30°C Homo sapiens
0.00219
-
zinc (2S)-2-amino-3-[([(2R)-3-[[(4-bromophenyl)(hydroxy)carbamoyl]sulfanyl]-1-[(carboxylatomethyl)amino]-1-oxopropan-2-yl]carbamoyl)amino]propanoate 0.05 M phosphate buffer pH 6.6, 30°C Homo sapiens
0.00628
-
(S)-4-bromobenzyl glutathione
-
Homo sapiens
0.0128
-
(2S)-2-amino-3-[([(2R)-3-[(4-bromobenzyl)sulfanyl]-1-[(carboxymethyl)amino]-1-oxopropan-2-yl]carbamoyl)amino]propanoic acid 0.05 M phosphate buffer pH 6.6, 30°C Homo sapiens