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Literature summary for 4.4.1.5 extracted from

  • Santel, T.; Pflug, G.; Hemdan, N.Y.; Schaefer, A.; Hollenbach, M.; Buchold, M.; Hintersdorf, A.; Lindner, I.; Otto, A.; Bigl, M.; Oerlecke, I.; Hutschenreuter, A.; Sack, U.; Huse, K.; Groth, M.; Birkemeyer, C.; Schellenberger, W.; Gebhardt, R.; Platzer, M.; Weiss, T.; Vijayalakshmi, M.A.; Krueger, M.
    Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity (2008), PLoS ONE, 3, e3508.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.4.1.5

Inhibitors

Inhibitors Comment Organism Structure
curcumin competitve inhibition, structually related to glutathione, Dixon plot analysis, pH 7.0, 30°C, more efficient inhibition of GLO1 compared to quercetin, myricetin, kaempferol, luteolin, or rutin as inhibitor, results in a decrease of D-lactate release Homo sapiens
kaempferol competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
luteolin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
myricetin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
quercetin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
rutin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from erythrocytes, purity above 90% Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
1321-N1 cell 1321N1 cell Homo sapiens
-
1321-N1 cell brain astrocytoma cell Homo sapiens
-
breast cancer cell MDA-MD-231 cell, JIMT-1 cell Homo sapiens
-
erythrocyte
-
 Homo sapiens
-
JIMT-1 cell breast cancer cell Homo sapiens
-
MDA-MB-231 cell breast cancer cell Homo sapiens
-
PC-3 cell prostate cancer cell Homo sapiens
-
prostate cancer cell PC-3 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.4
-
 breast cancer cell MDA-MD-231 cell, pH 7.0, 30°C Homo sapiens
0.9
-
 brain astrocytoma 1321N1 cell, pH 7.0, 30°C Homo sapiens
1.17
-
 breast cancer cell JIMT-1 cell, pH 7.0, 30°C Homo sapiens
1.4
-
 prostate cancer cell PC-3 cell, pH 7.0, 30°C Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0051
-
 curcumin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, competitive inhibition, pH 7.0, 30°C Homo sapiens
0.013
-
 myricetin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
0.021
-
 kaempferol in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
0.023
-
 quercetin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
0.035
-
 luteolin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
0.14
-
 rutin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens