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Literature summary for 4.4.1.5 extracted from
- Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro (2008), Ann. N. Y. Acad. Sci., 1126, 262-264.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of Glo1 in endothelial cells to investigate the effect on hyperglycemia-induced impairment of angiogenesis in vitro. The overexpression results in an increased protection against dicarbonyl glycation of endothelial cell protein protecting against hyperglycemia-induced angiogenesis deficit. The formation of tube structures through hyperglycemia decreases by 32% | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | Glo1 is the major cellular enzyme that catalyzes the metabolism of methylglyoxal and thereby protects against dicarbonyl glycation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HMEC-1 cell | human dermal microvascular endothelial cell | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
overexpression of Glo1 in human microvascular endothelial cells results in a 4fold increase in glyoxalase 1 activity | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Glo1 is the major cellular enzyme that catalyzes the metabolism of methylglyoxal and thereby protects against dicarbonyl glycation | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Glo1 | - |
Homo sapiens |
| glyoxalase 1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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