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Literature summary for 4.4.1.5 extracted from

  • More, S.S.; Vince, R.
    Design, synthesis, and binding studies of bidentate Zn-chelating peptidic inhibitors of glyoxalase-I (2007), Bioorg. Med. Chem. Lett., 17, 3793-3797.
    View publication on PubMed

Application

Application Comment Organism
drug development beta-ketoesters function as a possible zinc-chelating component of Glx-I inhibitors Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
L-gamma-glutamyl-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine tight-binding carboanalog of hydroxamate Saccharomyces cerevisiae
N-[(1S,4Z)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohept-4-en-1-yl]-L-glutamine beta-ketoester, competetive inhibitor Saccharomyces cerevisiae
N-[(1S,4Z)-6-(4-bromophenyl)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohex-4-en-1-yl]-L-glutamine beta-ketoester, competetive inhibitor Saccharomyces cerevisiae
N2-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine tight-binding carboanalog of hydroxamate Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
methylglyoxal
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + methylglyoxal
-
Saccharomyces cerevisiae S-D-lactoylglutathione
-
?

Synonyms

Synonyms Comment Organism
glyoxalase-I
-
Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000617
-
L-gamma-glutamyl-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine
-
Saccharomyces cerevisiae
0.0000326
-
N2-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine
-
Saccharomyces cerevisiae
0.06688
-
N-[(1S,4Z)-6-(4-bromophenyl)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohex-4-en-1-yl]-L-glutamine
-
Saccharomyces cerevisiae
0.1124
-
N-[(1S,4Z)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohept-4-en-1-yl]-L-glutamine
-
Saccharomyces cerevisiae