Application | Comment | Organism |
---|---|---|
drug development | beta-ketoesters function as a possible zinc-chelating component of Glx-I inhibitors | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-gamma-glutamyl-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine | tight-binding carboanalog of hydroxamate | Saccharomyces cerevisiae | |
N-[(1S,4Z)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohept-4-en-1-yl]-L-glutamine | beta-ketoester, competetive inhibitor | Saccharomyces cerevisiae | |
N-[(1S,4Z)-6-(4-bromophenyl)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohex-4-en-1-yl]-L-glutamine | beta-ketoester, competetive inhibitor | Saccharomyces cerevisiae | |
N2-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine | tight-binding carboanalog of hydroxamate | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
methylglyoxal | - |
Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + methylglyoxal | - |
Saccharomyces cerevisiae | S-D-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glyoxalase-I | - |
Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000617 | - |
L-gamma-glutamyl-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine | - |
Saccharomyces cerevisiae | |
0.0000326 | - |
N2-[[(2S)-2-amino-2-carboxyethyl]carbamoyl]-N-(4-bromophenyl)-N-hydroxy-L-glutaminylglycine | - |
Saccharomyces cerevisiae | |
0.06688 | - |
N-[(1S,4Z)-6-(4-bromophenyl)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohex-4-en-1-yl]-L-glutamine | - |
Saccharomyces cerevisiae | |
0.1124 | - |
N-[(1S,4Z)-1-[(carboxymethyl)carbamoyl]-4-hydroxy-6-oxohept-4-en-1-yl]-L-glutamine | - |
Saccharomyces cerevisiae |