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Literature summary for 4.4.1.5 extracted from

  • Lupidi, G.; Bollettini, M.; Venardi, G.; Marmocchi, F.; Rotilio, G.
    Functional residues on the enzyme active site of glyoxalase I from bovine brain (2001), Prep. Biochem. Biotechnol., 31, 317-329.
    View publication on PubMed
Search for more literature for 4.4.1.5

Inhibitors

Inhibitors Comment Organism Structure
1-ethyl-3-(3-dimethylaminopropyl) carbodiimide 10 mM, 65% inhibition Bos taurus
2,3-Butanedione time and concentration dependent inactivation Bos taurus
2,4,6-trinnitrobenzenesulphonic acid 2 mM, 60% inhibition Bos taurus
diethyldicarbonate 2 mM, complete inhibition Bos taurus
N-bromsuccinimide 0.0032 mM, 35% inhibition Bos taurus
p-hydroxymercuribenzene sulfonate 1 mM, 64% inhibition Bos taurus
Phenylglyoxal
-
 Bos taurus
S-hexylglutathione competitive inhibition Bos taurus
Tetranitromethane 2 mM, 30% inhibition Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione-methylglyoxal hemithioacetal Homo sapiens glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione (R)-S-lactoylglutathione
-
 ?
glutathione-methylglyoxal hemithioacetal Saccharomyces cerevisiae glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione (R)-S-lactoylglutathione
-
 ?
glutathione-methylglyoxal hemithioacetal Bos taurus glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione (R)-S-lactoylglutathione
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Saccharomyces cerevisiae
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione-methylglyoxal hemithioacetal glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione Homo sapiens (R)-S-lactoylglutathione
-
 ?
glutathione-methylglyoxal hemithioacetal glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione Saccharomyces cerevisiae (R)-S-lactoylglutathione
-
 ?
glutathione-methylglyoxal hemithioacetal glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione Bos taurus (R)-S-lactoylglutathione
-
 ?

Synonyms

Synonyms Comment Organism
glyoxalase I
-
 Homo sapiens
glyoxalase I
-
 Saccharomyces cerevisiae
glyoxalase I
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.4
-
 Phenylglyoxal
-
 Bos taurus
4.1
-
 2,3-Butanedione
-
 Bos taurus