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Literature summary for 4.4.1.22 extracted from

  • Gönrich, M.; Bartoschek, S.; Hagemeier, C.H.; Griesinger, C.; Vorholt, J.A.
    A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy (2002), J. Biol. Chem., 277, 3069-3072.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
x * 21000, SDS-PAGE Paracoccus denitrificans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-(hydroxymethyl)glutathione Paracoccus denitrificans the enzyme accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway glutathione + formaldehyde
-
?

Organism

Organism UniProt Comment Textmining
Paracoccus denitrificans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Paracoccus denitrificans

Reaction

Reaction Comment Organism Reaction ID
S-(hydroxymethyl)glutathione = glutathione + formaldehyde the enzyme from Paracoccus denitrificans accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway Paracoccus denitrificans

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
350
-
-
Paracoccus denitrificans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-(hydroxymethyl)glutathione
-
Paracoccus denitrificans glutathione + formaldehyde
-
?
S-(hydroxymethyl)glutathione the enzyme accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway Paracoccus denitrificans glutathione + formaldehyde
-
?

Subunits

Subunits Comment Organism
? x * 21000, SDS-PAGE Paracoccus denitrificans

Synonyms

Synonyms Comment Organism
EC 1.2.1.1 formerly, part transferred Paracoccus denitrificans
Gfa
-
Paracoccus denitrificans
glutathione-dependent formaldehyde-activating enzyme
-
Paracoccus denitrificans