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Literature summary for 4.4.1.21 extracted from
- Establishing bacterial communities by word of mouth: LuxS and autoinducer 2 in biofilm development (2008), Nat. Rev. Microbiol., 6, 635-643.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Staphylococcus aureus | LuxS is required for normal biofilm development | ? | - |
? |  |
| additional information | Haemophilus influenzae | LuxS is required for normal biofilm development | ? | - |
? | |
| additional information | Escherichia coli | LuxS is required for normal biofilm development | ? | - |
? | |
| additional information | Serratia plymuthica | LuxS is required for normal biofilm development | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Campylobacter jejuni | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Haemophilus influenzae | - |
- |
- |
| Helicobacter pylori | - |
- |
- |
| Serratia plymuthica | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
| Vibrio harveyi | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | luxS expression is detectable only at the base of fruiting bodies | Bacillus subtilis | - |
| additional information | luxS expression is detectable only at the base of fruiting bodies | Campylobacter jejuni | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | LuxS is required for normal biofilm development | Staphylococcus aureus | ? | - |
? | |
| additional information | LuxS is required for normal biofilm development | Haemophilus influenzae | ? | - |
? | |
| additional information | LuxS is required for normal biofilm development | Escherichia coli | ? | - |
? | |
| additional information | LuxS is required for normal biofilm development | Serratia plymuthica | ? | - |
? | |
| S-ribosylhomocysteine | - |
Staphylococcus aureus | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
| S-ribosylhomocysteine | - |
Haemophilus influenzae | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
| S-ribosylhomocysteine | - |
Bacillus subtilis | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
| S-ribosylhomocysteine | - |
Escherichia coli | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
| S-ribosylhomocysteine | - |
Vibrio harveyi | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
| S-ribosylhomocysteine | - |
Helicobacter pylori | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
| S-ribosylhomocysteine | - |
Serratia plymuthica | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
| S-ribosylhomocysteine | - |
Campylobacter jejuni | L-homocysteine + 4,5-dihydroxy-2,3-pentanedione | the reactive by-product of the LuxS-catalysed reaction 4,5-dihydroxy-2,3-pentanedione undergoes spontaneous cyclization reactions to form autoinducer 2 | ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LuxS | - |
Staphylococcus aureus |
| LuxS | - |
Haemophilus influenzae |
| LuxS | - |
Bacillus subtilis |
| LuxS | - |
Escherichia coli |
| LuxS | - |
Vibrio harveyi |
| LuxS | - |
Helicobacter pylori |
| LuxS | - |
Serratia plymuthica |
| LuxS | - |
Campylobacter jejuni |
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