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Literature summary for 4.4.1.21 extracted from

  • Shen, G.; Rajan, R.; Zhu, J.; Bell, C.E.; Pei, D.
    Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase (2006), J. Med. Chem., 49, 3003-3011.
    View publication on PubMed
Search for more literature for 4.4.1.21

Cloned(Commentary)

Cloned (Comment) Organism
LuxS variants are overexpressed in Escherichia coli in their Fe2+, Zn2+- and Co2+-substituted forms Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-4-[(2R,3R)-2,3-dihydroxy-3-N-hydroxycarbamoylpropylmercapto] butyric acid
-
 Escherichia coli
(2S)-2-amino-4-[(2R,3S)-2,3-dihydroxy-3-N-hydroxycarbamoylpropylmercapto] butyric acid
-
 Escherichia coli
D-erythronohydroxamic acid
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
 S-ribosylhomocysteine Co2+ substitued enzyme Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ Co2+ substitution produces a highly stable enzyme Escherichia coli
Fe2+ acts as a Lewis acid Escherichia coli
Zn2+ Zn2+ substitution produces an enzyme with 10-fold lower activity Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P45578
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine
-
 Escherichia coli L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione
-
 ?
S-ribosylhomocysteine
-
 Escherichia coli L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione
-
 ?

Synonyms

Synonyms Comment Organism
EcLuxS
-
 Escherichia coli
LuxS
-
 Escherichia coli
S-ribosylhomocysteinase
-
 Escherichia coli
S-ribosylhomocysteine lyase
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0032
-
 (2S)-2-amino-4-[(2R,3S)-2,3-dihydroxy-3-N-hydroxycarbamoylpropylmercapto] butyric acid Co2+ substituted enzyme Escherichia coli
0.0127
-
 (2S)-2-amino-4-[(2R,3R)-2,3-dihydroxy-3-N-hydroxycarbamoylpropylmercapto] butyric acid Co2+ substituted enzyme Escherichia coli
0.72
-
 D-erythronohydroxamic acid Co2+ substituted enzyme Escherichia coli