Application | Comment | Organism |
---|---|---|
medicine | aspirin desensitization may provide effective therapy for aspirin-exacerbated respiratory disease, at least in part, through mitigation of STAT6 expression, thereby downregulating LTC4S pathways | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aspirin | blocks the STAT6-dependent interleukin-4-inducible expression of LTC4S | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16873 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
THP-1 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
leukotriene C4 synthase | - |
Homo sapiens |
LTC4 synthase | - |
Homo sapiens |
LTC4S | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | no upregulation by interleukin-4 in the THP-1 cell line | down |