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Literature summary for 4.4.1.20 extracted from

  • Okubo, M.; Yamanaka, H.; Kobayashi, K.; Noguchi, K.
    Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain (2010), Glia, 58, 599-610.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q925U2 male Sprague Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
microglia
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Rattus norvegicus
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neuron
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Rattus norvegicus
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spinal cord throughout the gray matter Rattus norvegicus
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Synonyms

Synonyms Comment Organism
LTC4 synthase
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Rattus norvegicus
LTC4S
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Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus is not suppressed by pretreatment with the p38 inhibitor additional information
Rattus norvegicus LTC4s increases following spared nerve injury, significant increase 3 days after nerve injury and continues at least for 14 days. LTC4s mRNA is expressed constitutively throughout the grey matter and increases after nerve injury in dorsal horn. This increase in LTC4s mRNA mainly occurrs in cells with small nuclei up