Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16873 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eosinophil | co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies, 10% of LTC4 synthase-positive cells being eosinophils in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 19% of eosinophils | Homo sapiens | - |
macrophage | co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies. 10-43% of LTC4 synthase-positive cells being macrophages in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 6-76% of macrophages | Homo sapiens | - |
mast cell | co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies, 22-26% of LTC4 synthase-positive cells being mast cells in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 10-38% of mast cells, but it does not localize to mast cells in the normal biopsies | Homo sapiens | - |
additional information | nasal biopsies | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
LTC4 synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | expression in mast cells is not apparent in healthy subjects | down |
Homo sapiens | significantly elevated immunoexpression of LTC4 synthase observed in perennial allergic rhinitis biopsies | up |
General Information | Comment | Organism |
---|---|---|
physiological function | perennial allergic rhinitis biopsies show 3fold more cells immunostaining for LTC4 synthase compared with seasonal allergic rhinitis biopsies but this is not significant compared with normal biopsies, probably because normal biopsies show relatively high variability for LTC4 synthase | Homo sapiens |