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Literature summary for 4.4.1.20 extracted from

  • Westergren, V.S.; Wilson, S.J.; Penrose, J.F.; Howarth, P.H.; Sampson, A.P.
    Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis (2009), Clin. Exp. Allergy, 39, 820-828.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16873
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Source Tissue

Source Tissue Comment Organism Textmining
eosinophil co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies, 10% of LTC4 synthase-positive cells being eosinophils in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 19% of eosinophils Homo sapiens
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macrophage co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies. 10-43% of LTC4 synthase-positive cells being macrophages in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 6-76% of macrophages Homo sapiens
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mast cell co-localization for 5-lipoxygenase activating protein, LTC4 synthase, cyclooxygenase-1 and prostaglandin D2 synthase in nasal biopsies, 22-26% of LTC4 synthase-positive cells being mast cells in perennial and seasonal allergic rhinitis biopsies. In the rhinitic biopsies, LTC4 synthase is detectable in 10-38% of mast cells, but it does not localize to mast cells in the normal biopsies Homo sapiens
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additional information nasal biopsies Homo sapiens
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Synonyms

Synonyms Comment Organism
LTC4 synthase
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression in mast cells is not apparent in healthy subjects down
Homo sapiens significantly elevated immunoexpression of LTC4 synthase observed in perennial allergic rhinitis biopsies up

General Information

General Information Comment Organism
physiological function perennial allergic rhinitis biopsies show 3fold more cells immunostaining for LTC4 synthase compared with seasonal allergic rhinitis biopsies but this is not significant compared with normal biopsies, probably because normal biopsies show relatively high variability for LTC4 synthase Homo sapiens