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Literature summary for 4.4.1.20 extracted from

  • Martinez Molina, D.; Wetterholm, A.; Kohl, A.; McCarthy, A.A.; Niegowski, D.; Ohlson, E.; Hammarberg, T.; Eshaghi, S.; Haeggstroem, J.Z.; Nordlund, P.
    Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase (2007), Nature, 448, 613-616.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in the yeast Pichia pastoris with a His6 tag Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
its apo and GSH-complexed forms to 2.00 and 2.15 A resolution, using the sitting drop vapour diffusion technique Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16873
-
-

Purification (Commentary)

Purification (Comment) Organism
extraction with a Triton X-100/Triton-DOC mixture, two affinity chromatography steps and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + glutathione
-
Homo sapiens leukotriene C4
-
?

Subunits

Subunits Comment Organism
trimer each monomer is composed of four transmembrane segments Homo sapiens

Synonyms

Synonyms Comment Organism
leukotriene C4 synthetase
-
Homo sapiens
LTC4 synthase
-
Homo sapiens
LTC4S
-
Homo sapiens