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Literature summary for 4.4.1.20 extracted from
- Leukotriene C4 synthase (2003), Prostaglandins Leukot. Essent. Fatty Acids, 69, 111-116.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C56S | not inhibited by N-ethylmaleimide | Homo sapiens |
| R51I | inactive | Homo sapiens |
| Y93F | reduces the enzyme activity to less than 1% of the wild-type enzyme, shift in the pH-optimum | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Homo sapiens | |
| MK-886 | - |
Homo sapiens | |
| N-ethylmaleimide | inhibits the recombinant enzyme | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0036 | - |
leukotriene A4 | human recombinant enzyme | Homo sapiens | |
| 1.6 | - |
glutathione | human recombinant enzyme | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | inhibits the enzyme | Homo sapiens | |
| Mg2+ | augments the enzyme | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 18000 | - |
2 * 18000, SDS-PAGE, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene C4 | Homo sapiens | - |
leukotriene A4 + glutathione | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16873 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| KG-1 cell | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 | - |
r | |
| leukotriene C4 | - |
Homo sapiens | leukotriene A4 + glutathione | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 18000, SDS-PAGE, gel filtration | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| leukotriene C4 synthase | - |
Homo sapiens |
| LTC4 synthase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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