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Literature summary for 4.4.1.20 extracted from
- Molecular and catalytic properties of three rat leukotriene C4 synthase homologs (2003), Biochem. Biophys. Res. Commun., 312, 271-276.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Spodoptera frugiperda | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cysteinyl-leukotriene | - |
Rattus norvegicus |  |
| MK-886 | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0188 | - |
leukotriene A4 free acid | 4°C, pH 7.35 | Rattus norvegicus | |
| 0.0198 | - |
leukotriene A4 methyl ester | 4°C, pH 7.35 | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16800 | - |
calculated from amino acid sequence | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene C4 | Rattus norvegicus | - |
leukotriene A4 + glutathione | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q925U2 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0562 | - |
with leukotriene A4 free acid as substrate | Rattus norvegicus |
| 0.0813 | - |
with leukotriene A4 methyl ester as substrate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | free acid, 4°C, pH 7.35 | Rattus norvegicus | leukotriene C4 | - |
r | |
| leukotriene A4 free acid + glutathione | - |
Rattus norvegicus | leukotriene C4 | - |
? | |
| leukotriene A4 methyl ester + glutathione | 4°C, pH 7.35 | Rattus norvegicus | leukotriene C4 methyl ester | - |
r | |
| leukotriene C4 | - |
Rattus norvegicus | leukotriene A4 + glutathione | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| leukotriene C4 synthase | - |
Rattus norvegicus |
| LTC4S | - |
Rattus norvegicus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Rattus norvegicus | calculated from amino acid sequence | - |
9.69 |
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